REFERENCES FOR CHAPTER 9

Abbott, B.D.; Birnbaum, L.S. (1991). TCDD exposure of human embryonic palatal shelves in organ culture alters the differentiation of medial epithelial cells. Teratology 43: 119-132.

Ahlborg, U.G.; Becking, G.C.; Birnbaum, L.S.; Brouwer, A.; Derks, H.J.G.M.; Freeley, M.; Golor, G.; Hanberg, A.; Larsen, J.C.; Liem, A.K.D.; Safe, S.H.; Schlatter, C.; Waern, R.; Younes, M.; Yrjänheikki, E. (1994) Toxic equivalency factors for dioxin-like PCBs. Chemosphere 28(6): 1049-1067.

Air Force Health Study. (1991) An epidemiologic investigation of health effects in Air Force personnel following exposure to herbicides (Serum dioxin analysis of 1987 examination results).

Andersen, M.E.; Mills, J.J.; Gargas, M.L.; et al. (1993) Modeling receptor-mediated processes with dioxin: Implications for pharmacokinetics and risk assessment. Risk Anal. 13(1): 25-36.

Beck, H.; Eckart, K.; Mathar, W. (1989) Levels of PCDD's and PCDF's in adipose tissue of occupationally exposed workers. Chemosphere 18: 507-516.

Beck, H.; Dross, A.; Ende, M.; et al. (1991) Ergebnisse von Ruckstandsuntersuchungen auf polychlorierte Dibenzofurane und Dibenzodioxine in Frauenmilch aus der Bundesrepublik Deutschland [Results of the analysis for residue of polychlorinated dibenzodioxins and dibenzofurans in human milk from the Federal Republic of Germany]. Bundesgesundheitsblatt 34: 564-568.

Beck, H.; Dross, A.; Mathar, W. (1994) PCDD and PCDF exposure and levels in humans in Germany. Environ. Health Perspect. 102(Suppl 1): 173-185.

Bertazzi, P.A.; Pesatori, A.C.; Consinni, D.; Tironi, A.; Landi, M.T.; Zochetti, C. (1993) Cancer incidence in a population accidently exposed to 2,3,7,8-tetrachlorodibenzo-papa-dioxin. Epidemiology 4(5): 398-406.

Burelson, G.R.; Lebrec, H.; Yang, Y.; Ibanes, J.D.; Penningoton, K.N.; Birnbaum, L.S. (1994) Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza host resistance in mice. Fund. Appl. Toxicol; in press.

Carrier, G. (1991) Response de l’organiisme humain aux BPC, dioxines et furanneset analyse de risques toxiques. Passeur Press, Canada.

Carrier, G.; Brunet, R.; Brodeur, J. (Submitted) Physiologically-based modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. I. Nonlinear distribution of PCDD/PCDF body burden between liver and adipose tissue.

Chen, Y.-C.J.; Guo, Y.-L.; Hsu, C.-C.; Rogan, W.J. (1992) Cognitive development of Yu-Chen (`Oil Disease') children prenatally exposed to heat-degraded PCBs. J. Am. Med. Assoc. 268: 3213-3218.

Clark, G.; Tritscher, A.; Bell, D.; Lucier, G.W. (1992) Integrated approach for evaluating species and interindividual differences in responsiveness to dioxins and structural analogs. Environ. Health Perspect. 98: 125-132.

Cohen, G.M.; Bracken, W.P.; Iyer, R.P.; et al. (1979) Anticarcinogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene tumor initiation and its relationship to DNA binding. Cancer Res. 39: 4027-4033.

Columbia River Intertribal Fish Commission (1993) A fish consumption survey of the Umtilla, Nez Perce, Yakima, and Warm Springs tribes of the Columbia River Basin. Peer Review Draft Report.

Cook, J.C.; Dold, K.M.; Greenlee, W.F. (1987) An in vitro model for studying the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to human thymus. Toxicol. Appl. Pharmacol. 89: 256-268.

Couture, L.A.; Abbott, B.D.; Birnbaum, L.S. (1990) A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances toward understanding the mechanism. Teratology 42: 619-632.

DeVito, M.J.; Birnbaum, L.S. (1994) Toxicology of dioxin and related compounds. Toxicology; in press.

DeVito, M.J.; Maier, W.E.; Diliberto, J.J.; Birnbaum, L.S. (1993) Comparative ability of various PCBs, PCDFs, and TCDD to induce cytochrome P450 1A1 and 1A2 activity following 4 weeks of treatment. Fund. Appl. Toxicol. 20: 125-130.

DeVito, M.J.; Ma, X.; Babish, J.G.; Menache, M.; Birnbaum, L.S. (1994) Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor and protein tyrosine phosphorylation. 124: 82-90.

Dewailly, E.; Ryan, J.J.; Laliberte, C.; et al. (1994) Exposure of remote maritime populations to coplanar PCBs. Environ. Health Perspect. 102 (Suppl 1): 205-209.

DiGiovanni, J.; Berry, D.L.; Gleason, G.L.; et al. (1980) Time-dependent inhibition by 2,3,7,8-tetrachlorodibenzo-p-dioxin of skin tumorigenesis with polycyclic hydrocarbons. Cancer Res. 40: 1580-1587.

Diliberto, J.J.; Akube, P.I.; Luebke, R.W.; Birnbaum, L.S. (Submitted) Dose-response relationships of tissue distribution and induction of CYP1A1 and CYP1A2 enzymatic activities following acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice.

Egeland, G.M.; Sweeney, M.H.; Fingerhut, M.A.; Halperin, W.E.; Wille, K.K.; Schnoor, T.M. (1994) Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDD) effect on total serum testosterone and gonadotropins in occupationally exposed men. Amer. J. Epidemiol. 139: 272-281.

Enan, E.; Liu, P.C.; Matsumura, F. (1992) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes reduction of glucose transporting activities in the plasma membranes of adipose tissue and pancreas from the guinea pig. J Biol. Chem. 267: 19785-19791.

Fingerhut, M.A.; Halperin, W.E.; Marlow, B.S.; Piacetelli, L.A.; Honchar, P.A.; Sweeney, M.H.; Greife, A.L.; Dill, P.A.; Steenland, K.; Suruda, A.J. (1991) Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. N. Engl. J. Med. 342: 212-218.

Furst, P.; Furst, C.; Groebel, W. (1990) Levels of PCDDs and PCDFs in food stuffs from the Federal Republic of Germany. Chemosphere 20(7-9): 787-792.

Furst, P.; Furst, L.; Widmers, K. (1991) Body burden with PCDD and PCDF from food. In: Gallo, M.; Scheuplein, R.; Van der Heijden, K., eds. Biological basis for risk assessment of dioxin and related compounds. Banbury report No. 35. Plainview, NY: Cold Springs Harbor Laboratory Press.

Ganong W.F. (1982) Review of medical physiology, 11th ed. Los Altos, CA: Lange Medical Publications.

Gilman, A.; Newhook, R. (1991) An updated assessment of the exposure of Canadians to dioxins and furans. Chemosphere 23: 1661-1667.

Greenlee, W.F.; Dold, K.M.; Irons, R.D.; Osborne, R. (1985) Evidence for direct action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymic epithelium. Toxicol. Appl. Pharmacol. 79: 112-120.

Guo, Y.L.; Lin, C.J.; Yao, W.J.; Ryan, J.J.; Hsu, C.C. (1994) Musculoskeletal changes in children prenatally exposed to polychlorinated biphenyls and related compounds (Yu-Cheng children). J. Toxicol. Environ. Health 41: 83-93.

Harrad, S.J.; Jones, K.C. (1992) A source inventory and budget for chlorinated dioxins and furans in the United Kingdom environment. Science of the Total Environment 126: 89-107.

Hites, R.A. (1991) Atmospheric transport and deposition of polychlorinated dibenzo-p-dioxins and dibenzofurans. Prepared for the U.S. Environmental Protection Agency, Methods Research Branch, Atmospheric Research and Assessment Laboratory, Office of Research and Development, Research Triangle Park, NC. EPA/600/3-91/002.

Hong, R.; Taylor, K.; Abounor, R. (1989) Immune abnormalities associated with chronic TCDD exposure in rhesus monkeys. Chemosphere 18: 313-320.

Hsu, C.C.; Hu, H.F.; Lai, R.J.; Ko, H.C.; Chem, Y.C. (1993) Behavioral development of Yucheng children as compared to their matched controls. Dioxin '93 14: 239-242.

Johnson, R.D.; Tietge, J.E.; Botts, S. (1992) Carcinogenicity of 2,3,7,8-TCDD to Medaka. The Toxicologist 12(1): 138.

Kahn, P.C.; Gochfeld, M.; Nygren, M.; et al. (1988) Dioxins and dibenzofurans in blood and adipose tissue of Agent Orange-exposed Vietnam veterens and matched controls. J. Am. Med. Assoc. 259: 1661-1667.

Kedderis, L.B.; Mills, J.J.; Andersen, M.E.; Birnbaum, L.S. (1993) A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: Tissue distribution and CYP1A2 induction. Toxicol. Appl. Pharmacol. 121: 87-98.

Kociba, R.J.; Keyes, D.G.; Beyer, J.E.; Carreon, R.M.; Wade, C.E.; Dittenber, D.A.; Kalnins, R.P.; Frauson, L.E.; Park, C.N.; Barnard, S.D.; Hummel, R.A.; Humiston, C.G. (1978) Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol. Appl. Pharmacol. 46: 279-303.

Kogevinas, M.; Saracci, R.; Winkelman, R.; et al. (1993) Cancer incidence and mortality in women occupationally exposed to chlorophenoxy herbicides, chlorophenols and dioxins. Cancer Causes and Control, 4: 457.

Kohn, M.C.; Portier, C.J. (1993) Effects of the mechanism of receptor-mediated gene expression on the shape of the dose-response curve. Risk Analysis 13(5): 565-572.

Kohn, M.C.; Lucier, G.W.; Clark, G.C.; et al. (1993) A mechanistic model of effects of dioxin on gene expression in the rat liver. Toxicol. Appl. Pharmacol. 120: 138-154.

Lai, T.J.; Chen, Y.C.; Chou, W.J.; Guo, Y.L.; Ko, H.C.; Hsu, C.C. (1993) Cognitive development in Yucheng children. Dioxin '93 14: 247-250.

Leung, H.-W.; Paustenbach, D.J.; Murray, F.J.; Andersen, M.E. (1990a) A physiologically based pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Toxicol. Appl. Pharmacol. 103: 399-410.

Leung, H.-W.; Poland, A.P.; Paustenbach, D.J.; Andersen, M.E. (1990b) Dose dependent pharmacokinetics of [¹²⁵I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin in mice: Analysis with a physiological modeling approach. Toxicol. Appl. Pharmacol. 103: 411-419.

Lucier, G.W. (1991) Humans are a sensitive species to some of the biochemical effects of structural analogs of dioxin. Environment. Toxicol. Chem. 10: 727-735.

Lucier, G.W.; Tritscher, A.; Goldsworthy, T.; et al. (1991) Ovarian hormones enhance 2,3,7,8-TCDD mediated increases in cell proliferation and preneoplastic foci in a two-step model for rat hepatocarcinogenesis. Cancer Res. 51: 1391-1397.

Mably, T.A.; Moore, R.W.; Peterson, R.E. (1992a) In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. I. Effects on androgenic status. Toxicol. Appl. Pharmacol. 114: 97-107.

Mably, T.A.; Bjerke, D.L.; Moore, R.W.; Gendron-Fitzpatrick, A.; Peterson, R.E. (1992b) In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. III. Effects on spermatogenesis and reproductive capability. Toxicol. Appl. Pharmacol. 114: 108.

Manz, A.; Berger, J.; Dwyer, J.H.; et al. (1991) Cancer mortality among workers in a chemical plant contaminated with dioxin. Lancet 338: 959-964.

Maronpot, R.R.; Foley, J.F.; Takahashi, K.; Goldsworthy, T.; Clark, G.; Tritscher, A.; Portier, C.; Lucier, G. (1993) Dose response for TCDD promotion of hepatocarinogenesis in rats initiated with DEN: Histologic, biochemical and cell proliferation endpoints. Environ. Health Perspect. 101: 634-642.

McNulty, W.P. (1985) Toxicity and fetotoxicity of TCDD, TCDF, and PCB isomers in rhesus macaques (Macaca mulatta). Environ. Health Perspect. 60: 77.

MMWR (Morbidity and Mortality Weekly Report). (1988) Serum 2,3,7,8-tetrachloro-dibenzo-p-dioxin levels in Air Force health study participants—preliminary report. Centers for Disease Control, Atlanta, GA. 3(20): 309-311.

Moore, R.W.; Potter, C.L.; Theobald, H.M.; Robinson, J.A.; Peterson, R.E. (1985) Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 79: 99-111.

National Toxicology Program (NTP). (1980) Bioassay of a mixture of 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxin for possible carcinogenicity (gavage study). NTP Tech. Rept. Ser. no. 198. Research Triangle Park, NC: U.S. DHHS, PHS.

National Toxicology Program (NTP). (1982) Bioassay of 2,3,7,8-tetrachlorodibenzo-p-dioxin for possible carcinogenicity (gavage study). Technical report series No. 102, National Toxicology Program, Research Triangle Park, NC.

National Toxicology Program (NTP). (1982) Carcinogenicity bioassay of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Osborne-Mendel rats and B6C3F1 mice (gavage study). NTP Tech. Rept. Ser. no. 209. Research Triangle Park, NC: U.S. DHHS, PHS.

Neubert, R.; Jacob-Muller, U.; Helge, H.; Stahlmann, R.; Neubert, D. (1991) Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system 2. In vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on lymphocytes of venous blood from man and a non-human primate (Callithrix jacchus). Arch. Toxicol. 65: 213-219.

Neubert, R.; Golor, G.; Stahlmann, R.; Helge, H.; Neubert, D. (1992) Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 4. Effects of multiple dose treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on peripheral lymphocyte subpopulations of a non-human primate (Callithrix jacchus). Arch. Toxicol. 66: 250.

Patterson, D.G., Jr.; Needham, L.L.; Pirkle, J.L.; et al. (1988) Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri. Arch. Environ. Contam. Toxicol. 17: 139-143.

Patterson, D.G., Jr.; Todd, G.D.; Turner, W.E.; et al. (1994) Levels of non-ortho-substituted polychlorinated biphenyls, dibenzo-p-dioxins, and dibenzofurans in human serum and adipose tissue. Environ. Health Perspect. 102 (Suppl 1): 195-204.

Pirkle, J.L.; Wolfe, W.H.; Patterson, D.G., Jr.; et al. (1989) Estimates of the half-life of 2,3,7,8-TCDD in Vietnam veterans of Operation Ranch Hand. J. Toxicol. Environ. Health 27: 165-171.

Poiger, H.; Schlatter, C. (1986) Pharmacokinetics of 2,3,7,8-TCDD in man. Chemosphere 15(9-12): 1489-1494.

Poland, A.; Palen, D.; Glover, E. (1982) Tumor promotion by TCDD in skin of HRS/J hairless mice. Nature 300: 271.

Portier, C.; Tritscher, A.; Kohn, M.; Sewall, C.; Clark, G.; Edler, L.; Hoel, D.; Lucier, G. (1993) Ligand/receptor binding for 2,3,7,8-TCDD: Implications for risk assessment. Fund. Appl. Toxicol. 20: 48-56.

Probst, M.R.; Reisz-Porszasz, S.; Agbunag, R.V.; Ong, M.S.; Hankinson, O. (1993) Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Mol. Pharmacol. 44: 511-518.

Puvel, S.M.; Sakamoto, M. (1988) Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine skin. J. Invest. Dermatol. 90: 354-358.

Rao, M.S.; Subbaro, V.; Prasad, J.D.; Scarpelli, D.C. (1988) Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Syrian hamster. Carcinogenesis 9(9): 1677-1679.

Rappe, C. (1991) Sources of human exposure to PCDDs and PCDFs. In: Gallo, M.; Scheuplein, R.; Van der Heijam, K., eds. Biological basis for risk assessment of dioxin and related compounds. Banbury report No. 35. Plainview, NY: Cold Springs Harbor Laboratory Press.

Reier, S.E.; Martin, D.C.; Bowman, R.E.; Dmowski, W.P.; Becker, J.L. (1993) Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fund. Appl. Toxicol. 21: 433-441.

Rogan, W.J.; Gladen, B.C.; Hung, K.-L.; Koong, S.-L.; Shih, L.-Y.; Taylor, J.S.; Wu, Y.-C.; Yang, D.; Ragan, N.B.; Hsu, C.-C. (1988). Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science 241: 334-336.

Rose, J.Q.; Ramsey, J.C.; Wentzler, T.H.; Hummel, R.A.; Gehring, P.J. (1976) The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat. Toxicol. Appl. Pharmacol. 36: 209.

Roth, W.L.; Weber, L.W.D.; Stahl, B.U.; Rozman, K. (1993) A pharmacodynamic model of triglyceride transport and deposition during feed deprivation or following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat. Toxicol. Appl. Pharmacol. 120: 126-137.

Ryan, J.J.; Gasiewicz, T.A.; Brown, J.R., Jr. (1990). Human body burden of polychlorinated dibenzofurans associated with toxicity based on the Yusho and Yucheng incidents. Fund. Appl. Toxicol. 15: 722.

Safe, S. (1990) Polychlorinated biphenyls, dibenzo-p-dioxins, and dibenzofurans and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors. CRC Crit. Rev. Toxicol. 21: 51-88.

Saracci, R.; Kogevinas, M.; Beratzzi, P.; et al. (1991) Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols. Lancet 38(3774): 1027-1032.

Sauer, R.M. (1990) 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats. Submitted to the Maine Science Advisory Panel by Pathco, Inc., Ijamsville, MD, March 13, 1990.

Schantz, S.L.; Bowman, R.E. (1989). Learning in monkeys exposed perinatally to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Neurotoxicol. Teratol. 11: 13.

Schecter, A. (1991) Dioxins and related compounds in humans and the environment. In: Gallo, M.; Scheuplein, R.; Van der Heijden, K., eds. Biological basis for risk assessment of dioxin and related compounds. Banbury report No. 35. Planview, NY: Cold Springs Harbor Laboratory Press.

Schecter, A.; Papke, O.; Ball, M.; Startin, J.R.; Wright, C.; Kelly, M. (1992) Dioxin and dibenzofuran levels in food from the United States as compared to levels in food from other industrialized countries. 12th International Symposium on Dioxins and Related Compounds; Tampere, Finland; August 1992. Finnish Institute of Occupational Health, Helsinki, Finland, pp. 243-246.

Schwetz, B.A.; Norris, J.M.; Sparschu, G.L.; Rowe, U.K.; Gehring, P.J.; Emerson, J.L.; Gerbig, C.G. (1973) Toxicology of chlorinated dibenzo-p-dioxins. Environ. Health Perspect. 5: 87.

Sewall, C.H.; Lucier, G.W.; Tritscher, A.M.; Clark, G.C. (1993) TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD. Carcinogenesis 14: 1885-1893.

Sielken, R.L., Jr. (1987) Statistical evaluations reflecting the skewness in the distribution of TCDD levels in human adipose tissue. Chemosphere 16(8/9): 2135-2140.

Spink, D.C.; Lincoln, D.C.; Dickerman, H.W.; Gierthy, J.F. (1990) 2,3,7,8-Tetra-chlorodibenzo-p-dioxin causes an extensive alteration in 17b -estradiol metabolism in MCF-7 breast tumor cells. Proc. Natl. Acad. Sci. USA. 87: 6917-6921.

Squire, R.A. (1980) Pathologic evaluations of selected tissues from the Dow Chemical TCDD and 2,4,5-T rat studies. Submitted to Carcinogen Assessment Group, U.S. Environmental Protection Agency on August 15 under contract no. 68-01-5092.

Sutter, T.R.; Guzman, K.; Dold, K.M.; Greenlee, W.F. (1991) Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1B. Science 254: 415-418.

Svensson, B.G.; Neisson, A.; Hansson, M.; et al. (1991) Exposure to dioxins and dibenzofurans through consumption of fish. N. Engl. J. Med. 324(1): 8-12.

Sweeney, M.H.; Hornung, R.W.; Wall, D.K.; Fingerhut, M.A.; Halperin, W.E. (1992) Prevalence of diabetes and elevated serum glucose levels in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Presented at 12th International Symposium on Dioxins and Related Compounds: August 24-28, Tampere, Finland.

Theelen, R.M.C. (1991) Modeling of human exposure to TCDD and I-TEQ in the Netherlands: background and occupational. In: Gallo, M.; Scheuplein, R.; Van der Heijden, K., eds. Biological basis for risk assessment of dioxin and related compounds. Banbury report No. 35. Plainview, NY: Cold Springs Harbor Laboratory Press.

Tritscher, A.M.; Goldstein, J.A.; Portier, C.J.; McCoy, Z.; Clark, G.C.; and Lucier, G.W. (1992) Dose response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: Quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. Cancer Res. 52: 3436-3442.

U.S. Environmental Protection Agency. (1989) Interim procedures for estimating risks associated with exposures to mixtures of chlorinated dibenzo-p-dioxins and dibenzofurans (CDDs and CDFs) and 1989 update. Risk Assessment Forum, EPA/625/3-89/016. National Technical Information Service, Springfield, VA; PB90-145756.

U.S. Environmental Protection Agency. (1991) Chlorinated dioxins and furans in the general U.S. population: NHATS FY87 results. Washington, D.C.: Office of Toxic Substances. EPA-560/5-91-003.

U.S. Environmental Protection Agency. (1994) Estimating exposure to dioxin-like compounds. Prepared by the Office of Health and Environmental Assessment, Office of Research and Development, Washington, DC. External Review Draft, 3 vol. EPA/600/6-88/005Ca, Cb, Cc.

U.S. Environmental Protection Agency Science Advisory Board. (1989) Review of draft documents: A cancer risk specific dose estimate for 2,3,7,8-TCDD and estimating exposures to 2,3,7,8-TCDD. Washington, D.C.: EPA Science Advisory Board Ad Hoc Dioxin Panel.

Van den Heuvel, J.P.; Clark, G.C.; Kohn, M.C.; Tritscher, A.M.; Greenlee, W.F., Lucier, G.W.; Bell, D.A. (1994) Dioxin-responsive genes: Examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. Cancer Res. 54: 62-68.

Wendling, J.M.; Orth, R.G. (1990) Determination of [³H]-2,3,7,8-tetrachlorodibenzo-p-dioxin in human feces to ascertain its relative metabolism in man. Anal. Chem. 62: 796-800.

White, T.E.K.; Gasiewicz, T.A. (1993) The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: A possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. Biophys. Res. Comm. 193: 956-962.

Whitlock, J. P., Jr. (1990) Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Ann. Rev. Pharmacol. Toxicol. 30: 251-277.

Wolfe, W.; Michalek, J.; Miner, J. Needham, L.; Patterson, D.; Jr. (1992) Diabetes versus dioxin body burden in veterans of Operation Ranch Hand. Presented at 12th International Symposium on Dioxins and Related Compounds; August 24-28; Tampere, Finland.

Wolfe, W.H.; Michalek, J.E.; Miner, J.C.; et al. (1994) Determinants of TCDD half-life in veterans of Operation Ranch Hand. J. Toxicol. Environ. Health 41: 481-488.

Wood, S.C.; Jeong, H.G.; Morris, D.L.; Holsapple, M.P. (1993) Direct effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on human tonsilar lymphocytes. Toxicology 81:131-143.

World Health Organization (WHO). (1988) PCBs, PCDDs, and PCDFs in breast milk: Assessment of health risks. Environ. Health 29.

Zinkl, J.G.; Vos, J.G.; Moore, J.A.; Gupta, B.N. (1973) Hematologic and clinical chemistry effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals. Environ. Health Perspect. 5: 111-118.

Zober, A.; Messerer, P.; Huber, P. (1990) Thirty-four year follow-up of BASF employees exposed to 2,3,7,8-TCDD after the 1953 accident. Int. Arch. Occup. Environ. Health 62: 138-157.